Imaging the Immune System
September 19-21, 2018, Paris

Wednesday, September 19, 2018
12:30 pm-12:45 pm
Welcome address
01:45 pm-02:00 pm
Keynote Speaker: Ron Germain
02:00 pm-02:45 pm
02:00 pm

Introduction by Philippe Bousso

02:05 pm

Visualizing Immunity – Combining Dynamic Intravital and Highly Multiplex Static Imaging to Better Understand Immune System Organization and Function

R. Germain
NIH, United States 
Session 1. Cell-cell interactions within the immune system
03:00 pm-06:30 pm
Chair: Stein Jens, Bern University, Switzerland
03:00 pm

Fast tracks and niches – novel immunobiological functions of lymphoid stromal cells

M. Bajenoff
CIML, France 
03:30 pm

Innate Immune Cell Dynamics in the Tissue Interstitium

T. Lämmermann
04:00 pm

DC-T cell interactions from a spatiotemporal perspective

W. Kastenmueller
IEI Bonn, Germany 
04:30 pm

Coffee break

05:00 pm

Mechanisms of tumor immunotherapies dissected at the single-cell level

P. Bousso
Institut Pasteur, France 
05:30 pm

Spatiotemporal dynamics of CD8+ T cells within the liver

M. Iannacone
San Raffaele Scientific Institute , Italy 
06:00 pm

Understanding Skin Immune Responses by Multiphoton and Light Sheet Microscopy

L.G. Ng
Functional Immune Imaging, Singapore Immunology Network (A*STAR), Singapore, Singapore 
06:15 pm

Dissection of cellular niches by multi-dimensional tissue imaging

Y. Goltsev*, N. Samusik, J. Kennedy-Darling, G. Nolan
3220 CCSR, Baxter lab, Department of Microbiology and Immunology, Stanford, Stanford, United States 
Poster session
06:30 pm-08:00 pm
Speaker dinner
08:30 pm-10:30 pm
Thursday, September 20, 2018
Session 2. Immune cells and tissue homeostasis
09:00 am-12:30 pm
Chair: Bajenoff Marc, CIML, France
09:00 am

Microglia in the development of early cortical circuits

S. Garel
ENS, France 
09:30 am

Guardians of the gut homeostasis: epithelial renewal and subepithelial macrophages

D. Vignjevic
Institut Curie, France 
10:00 am

What can we learn from imaging intravascular inflammation?

A. Hidalgo
CNIC, Spain 
10:30 am

Coffee break

11:00 am

Host microbe interaction at mucosal surfaces

M. Rescigno
IEO, Italy 
11:30 am

Detecting Death and Damage; Imaging macrophage migration in Drosophila

W. Wood
University of Bristol, United Kingdom 
12:00 pm

Genetic impact on epithelial immune cell homeostasis revealed by a large-scale automated image analysis of mouse epidermis

D. Ushakov*1, A. Lorenc1, K. Hng1, S. Caetano1, E. Cambridge2, A. Laing1, J. White2, L. Abeler-Dörner1, A.C. Hayday1-3
1King's College London, London, United Kingdom 2Wellcome Trust Sanger Institute, Cambridge, United Kingdom 3The Francis Crick Institute, London, United Kingdom 
12:15 pm

The Immune System Profoundly Restricts Tumor clonal Heterogeneity

I. Milo*1, M. Bedora-Faure2, Z. Garcia1, L. Périé3, G. Shakhar4, L. Deriano2, P. Bousso1
1Department of Immunology, INSERM U1223, Dynamique des Réponses Immunes, Institut Pasteur, Paris, France 2Department of Immunology and Department of Genomes and Genetics, Institut Pasteur, Paris, France 3PSL Research University, CNRS UMR168, Institut Curie, Paris, France 4Department of Immunology, Weizmann Institute of Science, Rehovot, Israel 
12:30 pm-02:00 pm
Session 3. Trafficking of Immune cells
02:00 pm-05:30 pm
Chair: Sixt Michael, IST, Austria
02:00 pm

Lymph node homing of lymph-derived immune cells

R. Forster
MH-Hannover, Germany 
02:30 pm

New insights into leukocyte migration through afferent lymphatics

C. Halin
ETH, Switzerland 
03:00 pm

Tissue patrol by resident memory CD8 T cells in human skin

F. Dijkgraaf*1, T. Dos Reis Matos2, M. Hoogenboezem3, M. Toebes1, M. Mertz4, B. Van Den Broek4, J. Song5, M. Teunissen2, R. Luiten2, J. Beltman6, T. Schumacher1
1Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands 2Department of Dermatology, Academic Medical Center, Amsterdam, The Netherlands 3Department of Molecular Cell Biology, Sanquin, Amsterdam, The Netherlands 4Digital Microscopy Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands 5Animal Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands 6Research Division of Drug Discovery and Safety, Leiden University, Amsterdam, The Netherlands 
03:15 pm

Dynamics of B cell selection for germinal center infiltration in Peyer’s patches

A. Biram1, A. Strömberg2, E. Winter3, L. Stoler-Barak1, R. Salomon1, Y. Addadi4, R. Dahan1, G. Yaari3, M. Bemark2, Z. Shulman*1
1Department of Immunology, Weizmann Institute of Science, Rehovot, Israel 2Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden 3Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel 4Department of Life Science Core facilities, Weizmann Institute of Science, Rehovot, Israel 
03:30 pm

Coffee break

04:00 pm

Defining the roads travelled by neutrophils to reach inflamed sites

M. Gunzer
University of Duisburg-Essen, Germany 
04:30 pm

A bug's view of the immune response: Using pathogen-encoded biosensors for dissecting containment mechanisms in vivo

A. Muller
Helmholtz center for infection research, Germany 
05:00 pm

Macropinocytosis overcomes directional bias due to hydraulic resistance to enhance space exploration by dendritic cells 

H. Moreau*1, C. Blanch-Mercader2, R. Attia3, Z. Alraies1, M. Maurin1, P. Bousso4, JF. Joanny2-5, R. Voituriez6, M. Piel3, AM. Lennon-Duménil1
1INSERM U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France 2Laboratoire PhysicoChimie Curie, Institut Curie, PSL Research University - Sorbonne Universités, UPMC – CNRS. Equipe labellisée Ligue Contre le Cancer, Paris, France 3Institut Curie, PSL Research University, CNRS, UMR 144 - Institut Pierre-Gilles de Gennes, PSL Research University, Paris, France 4Institut Pasteur, Dynamics of Immune Responses Unit - INSERM U1223, Paris, France 5ESPCI Paris-Tech, Paris, France 6Laboratoire Jean Perrin, UM 8237 CNRS/UPMC, Paris, France 
05:15 pm

Collective behaviour of CD8 T cells

L. Uhl1, J. Mahale1, AM. Mujal2, J. Mazet1, MF. Krummel2, A. Gerard*1
1The Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom 2UCSF, San Francisco, United States 
Conference dinner (musée d’Orsay)
08:30 pm-23:00
Friday, September 21, 2018
Keynote Speaker: Ron Vale
09:00 am-10:00 am
09:00 am

Introduction by Ana-Maria Lennon-Dumenil

09:05 am

Similarities between Signaling Systems Involved in Phagocytosis and T Cell Activation

R. Vale
UCSF, United States 
Session 4. Immune cell dynamics I : physical insights
10:00 am-12:30 pm
Chair: Lämmermann Tim, Max Planck Institute of Immunobiology and Epigenetics, Germany
10:00 am

Building and deconstructing the immunological synapse

M. Dustin
Kennedy Institute Rheumatology, United States 
10:30 am

Coffee break

11:00 am

DC migration: from micro-fluidics to in vivo imaging

A. Lennon-Dumenil
Institut Curie, France 
11:30 am

Mechanisms and consequences of large cell and nuclear deformation during immune cell migration

M. Piel
Institut Curie, France 
12:00 pm

Visualizing chemokine control of neutrophil behavior at sites of tissue damage

M. Sarris
Cambridge University, United Kingdom 
Session 5. Immune cell dynamics II : molecular insights
02:00 pm-04:00 pm
Chair: Sarris Milka, Cambridge University, United Kingdom
02:00 pm

Human cDC2 and tonsil macrophages have complementary roles for the induction of T follicular helper cells

M. Durand1, T. Walter2, P. Gueguen1, O. Ornatsky3, T. Vassilevskaia3, S. Amigorena1, E. Segura*1
1INSERM U932, Institut Curie, Paris, France 2U900, Institut Curie, Paris, France 3Fluidigm, Markham, Canada 
02:15 pm

Spatiotemporal regulation of type I interferon expression determines antiviral CD4+ T cell polarization

M. De Giovanni*1, C. Maganuco1-2, V. Cutillo1-2, C. Cristofani1-2, P. Di Lucia1, E. Bono1-2, L. Giustini1, D. Pinschwer3, M. Kuka1-2, M. Iannacone4-1
1Dynamics of Immune Responses, Ospedale San Raffaele srl, Milan, Italy 2Università Vita Salute San Raffaele, Milan, Italy 3University of Basel, Basel, Switzerland 4Experimental imaging center, Milan, Italy 
02:30 pm

To stop or not to stop: the LFA-1-ICAM-1 pair in antigen-specific T cell contacts with dendritic cells

R. Alon
Weizmann Institute, Israel 
03:00 pm

Molecular mechanisms underlying tissue-resident T cell-mediated immune surveillance

J. Stein
Bern University, Switzerland 
03:30 pm

How leukocytes navigate along the path of least resistance

M. Sixt
IST, Austria 
Concluding remarks
04:00 pm-04:15 pm

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